Yale researchers have introduced countless medical and health advances over the last century, including the first success with antibiotics in the United States and the first use of chemotherapy to treat cancer. University scientists have been responsible for the identification of Lyme disease and the discovery of genes responsible for high blood pressure, osteoporosis, dyslexia, and Tourette's syndrome, among other disorders. Early work on the artificial heart and the creation of the first insulin pump took place at Yale, as did seminal discoveries about how the cell and its components function at the molecular level. Today, research activities take place in a wide range of departments, programs, and centers.
As of fiscal year 2013 Yale research has had 1,815 awards totaling $510.4 million, 416 U.S. and 704 worldwide active patents for Yale inventions, and 58 Yale-founded biotech companies.
The School of Medicine has extraordinary strength in the basic sciences and consistently ranks in the top handful of medical schools receiving funding from the National Institutes of Health.
Productive and prominent programs in both basic and clinical research are fundamental to the development of clinical excellence and our academic mission.
Dr. Sarac's research is two pronged. The first component is large clinical series and trials investigating traditional and emerging outcomes in Vascular Surgery. Several areas of his interests have become national CME papers for the JVS. The second component is translational research, looking into improved outcomes through new device development. Dr. Sarac has been granted over 20 issued US and international patents, and has invented a tissue lined stent graft, percutaneous heart valve, percutaneous endograft, and numerous delivery systems. He currently is working on a gutterless chimney endograft, and adjustable endograft.
Dr. Sumpio's Vascular Biology Laboratory has both national and international visibility and is well-funded through NIH, AHA, and VA sources. This vigorous research program, focusing on delineating molecular events in the arterial wall in response to mechanical forces, has involvement by students, residents, visiting fellows, as well as faculty.
Dr. Alan Dardik is a surgeon-scientist who seeks to use the power of molecular biology to achieve a modern understanding of vascular disease, and to use the basic science laboratory to perform cutting edge research to ultimately benefit patients with vascular disease. The Dardik laboratory studies the healing and function of blood vessels and synthetic blood vessel substitutes that are used in patients having vascular bypass surgery. The laboratory is funded from NIH NHLBI and the VA, as well as from the Yale Department of Surgery. As part of Yale's Vascular Biology and Therapeutios program, the lab is located on the 4th floor of the Amistad building. Members of the Dardik laboratory include surgery residents from Yale and other programs as well as postdoctoral fellows and students from Japan, China, Lebanon and France.